Comparison of serum total antioxidant capacity between subjects with and without metabolic syndrome according their body mass index
-
Atefeh Hasaninasab
,
Alireza Esteghamati
,
Kamal Azam
,
Somaye Yosaee
,
Nahal Habibi
,
Kurosh Djafarian
Abstract
Background: This study aimed to determine the differences in plasma total antioxidant capacity between metabolic syndrome patients and those without metabolic syndrome with normal weight, overweight, and obesity.
Methods: A case-control study was carried out among 146 men and women (aged 20-55 years) in Endocrinology Center of Tehran University of Medical Sciences. The case group included overweight/obese subjects with metabolic syndrome and the two control groups were weight-matched subjects without metabolic syndrome and normal weight subjects without metabolic syndrome. Total antioxidant capacity was determined using the colorimetric method.
Results: Waist circumference and total antioxidant capacity of the case group were significantly higher than that of both control groups ((p<0.001) for both). There was no significant difference between normal and overweight/obese control groups in total antioxidant capacity level (p=0.53).
Conclusion: Oxidative stress presumably is an important factor in the pathology of metabolic syndrome and total antioxidant capacity may be responsible for defense against oxidants.
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22. Li Y, Chen S, Shao X et al. (2014) Association of Uric Acid withMetabolic Syndrome in Men, Premenopausal Women and Postmenopausal Women. Int J Environ Res Public Health 11(3), 2899–2910.
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28. Li Q, Yang Z, Lu B et al. (2011) Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol 10, 72.
29. Pasaoglu H, Sancak B, Bukan N. (2004) Lipid peroxidation resistance to oxidation in patients with type 2 diabetes mellitus. Tohoku J Exp Med 203(3), 211–8.
2. Alberti KG, Zimmet P, Shaw J. (2005) IDF epidemiology task force consensus group. The metabolic syndrome: a new worldwide definition. Lancet 366(9491), 1059–1062.
3. Amirkalali B, Fakhrzadeh H, Sharifi F, et al. (2015) Prevalence of Metabolic Syndrome and Its Components in the Iranian Adult Population: A Systematic Review and Meta-Analysis. Iran Red Crescent Med J 17(12).
4. Matsuda M, Shimomura I. (2013) Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Obes Res ClinPract 7(5), e330-41.
5. Abete I, Goyenechea E, Zulet, MA, Martinez JA. (2011) Obesity and metabolic syndrome: potential benefit from specific nutritional components. Nutr Metab Cardiovasc Dis 21 Suppl 2, B1-15.
6. Lee NK, Sowa H, Hinoi E et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130(3), 456-69.
7. Hanley AJ, Williams K, Stern MP, Haffner SM (2002): Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. Diabetes Care 25: 1177–1184.
8. Korkmaz GG, Altınoglu E, Civelek S et al. (2013) The association of oxidative stress markers with conventional risk factors in the metabolic syndrome. Metabol 62, 828–835.
9. Hasnain MW, Victor RV, Hollett, B. (2012) Weight gain and glucose dysregulation with second-generation antipsychotics and antidepressants: A review for primary care physicians. Postgrad Med 124, 154–167.
10. Nakao YM, Miyawaki T, Yasuno S et al. (2012) Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: Metabolic syndrome and abdominal obesity (MERLOT study). Proc Jpn Acad Ser B Phys Biol Sci 88, 454–61.
11-JC Seidell, J Halberstadt ,(2015)The global burden of obesity and the challenges of prevention, Ann Nutr Metab66(suppl 2):7-12
12. Gersh BJ, Maron BJ, Bono w RO et al. (ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;124:e783–831.
13. Dehghan M, Merchant AT. (2008) Is bioelectrical impedance accurate for use in large epidemiological tudies? Nutr J 7(1), 26.
14. Kutac P, Gajda V, Pridalova M, Šmajstrla V. (2008) Validity of measuring body composition by means of the BIA Method. Borgis – New Medicine 4, 89-93.
15. Ferrari CKB. (2008) Metabolic Syndrome and Obesity: Epidemiology and Prevention by Physical Activity and Exercise. J Exerc Sci Fit 6, 87-96.
16. Erel O. (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinbiochem 37, 277– 285.
17. Chen F, Wang Y, Shan X et al. (2012) Association between childhood obesity and metabolic syndrome: evidence from a large sample of Chinese children and adolescents. PloS One 7(10), e47380.
18. Faienza MF, Francavilla R, Goffredo R et al. (2012) Oxidative Stress in Obesity and Metabolic Syndrome in Children and Adolescents. Horm Res Paediatr 78(3), 158-64.
19. Skalicky J, Muzakova V, Kandar R et al. (2008) Evaluation ofoxidative stress and inflammation in obese adults with metabolic syndrome. ClinChem Lab Med 46, 499–505.
20. Hashemi M, Kordi-Tamandani DM, Sharifi N et al. (2011) Serum paraoxonase and arylesterase activities in metabolic syndrome in Zahedan, southeast Iran. Eur J Endocrinol 164(2), 219-22.
21. Kwak HK, Yoon S. (2007) Relation of serum total antioxidant status with metabolic risk factors in Korean adults. Nutr Res Pract 1(4), 335-40.
22. Li Y, Chen S, Shao X et al. (2014) Association of Uric Acid withMetabolic Syndrome in Men, Premenopausal Women and Postmenopausal Women. Int J Environ Res Public Health 11(3), 2899–2910.
23. Venturini D, Simão AN, Scripes NA et al. (2012) Evaluation of Oxidative Stress in Overweight Subjects With or Without Metabolic Syndrome. Obesity 20(12), 2361–2366.
24. Simao A, lozovoy MA, dichi I. (2012) The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome. Expert Opin Ther Targets 16(12), 1175-87.
25. Fabbrini E, Serafini M, Colic Baric I et al. Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes. Published online: 2014. Doi: 10.2337/db13-1396.
26. Palmer TM, Nordestgaard BG, Benn M et al. (2013) Association of plasma uric acid with ischemic heart disease and blood pressure: mendelian randomization analysis of two large cohorts. BMJ 4262, 1-10.
27. Uaratanawong S, Suraamornkul S, Angkeaw S, Uaratanawong R. (2011) Prevalence of hyperuricemia in Bangkok population. Clin Rheumatol 30(7), 887–893.
28. Li Q, Yang Z, Lu B et al. (2011) Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol 10, 72.
29. Pasaoglu H, Sancak B, Bukan N. (2004) Lipid peroxidation resistance to oxidation in patients with type 2 diabetes mellitus. Tohoku J Exp Med 203(3), 211–8.
| Files | ||
| Issue | Vol 2, No 3 (Summer 2016) | |
| Section | Original Article(s) | |
| Keywords | ||
| metabolic syndrome oxidative stress total antioxidant capacity body mass index | ||
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How to Cite
1.
Hasaninasab A, Esteghamati A, Azam K, Yosaee S, Habibi N, Djafarian K. Comparison of serum total antioxidant capacity between subjects with and without metabolic syndrome according their body mass index. J Nutr Sci & Diet. 2017;2(3).
