Comparison of serum total antioxidant capacity between subjects with and without metabolic syndrome according their body mass index
Background: This study aimed to determine the differences in plasma total antioxidant capacity between metabolic syndrome patients and those without metabolic syndrome with normal weight, overweight, and obesity.
Methods: A case-control study was carried out among 146 men and women (aged 20-55 years) in Endocrinology Center of Tehran University of Medical Sciences. The case group included overweight/obese subjects with metabolic syndrome and the two control groups were weight-matched subjects without metabolic syndrome and normal weight subjects without metabolic syndrome. Total antioxidant capacity was determined using the colorimetric method.
Results: Waist circumference and total antioxidant capacity of the case group were significantly higher than that of both control groups ((p<0.001) for both). There was no significant difference between normal and overweight/obese control groups in total antioxidant capacity level (p=0.53).
Conclusion: Oxidative stress presumably is an important factor in the pathology of metabolic syndrome and total antioxidant capacity may be responsible for defense against oxidants.
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