Association of retinol binding protein 4 and insulin resistance: a review on molecular mechanisms
Abstract
Retinol (ROH) and its derivatives named vitamin A are substantial for several cells’ functions. Retinol Binding Protein 4 (RBP4) is known as the career for vitamin A in blood. The main receptor for RBP4 is Stimulated by retinoid acid gene 6 (STRA6). RBP4 circulates in bound with Transports Thyroxine and Retinol (TTR) to form ternary ROH-RBP-TTR complex. Recently, RBP4 implicated in insulin resistance which may exerts its functions through inflammatory pathways. Although studies indicated that RBP4 may have role in inflammation as an adipocytokine. the cellular and molecular mechanisms including the interaction between Holo- or Apo-RBP4 and their receptor to induce inflammation is controversial. In this review, we focus on molecular structure of RBP4, STRA6, and their interaction to induce inflammation and insulin resistance to illustrate the potential conflicts in this area.
1. Mark M, Ghyselinck NB, Chambon P. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol. 2006;46:451-80.
2. Evans R. The molecular basis of signaling by vitamin A and its metabolites. Harvey lectures. 1994;90:105.
3. Wongsiriroj N, Piantedosi R, Palczewski K, Goldberg IJ, Johnston TP, Li E, et al. The molecular basis of retinoid absorption: a genetic dissection. The Journal of biological chemistry. 2008;283(20):13510-9.
4. Soprano DR, Soprano KJ, Goodman DS. Retinol-binding protein messenger RNA levels in the liver and in extrahepatic tissues of the rat. Journal of lipid research. 1986;27(2):166-71.
5. Berry DC, Jin H, Majumdar A, Noy N. Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. Proceedings of the National Academy of Sciences. 2011;108(11):4340-5.
6. Berry DC, Noy N. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2012;1821(1):168-76.
7. Berry DC, O'Byrne SM, Vreeland AC, Blaner WS, Noy N. Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6. Molecular and cellular biology. 2012;32(15):3164-75.
8. Berry DC, Croniger CM, Ghyselinck NB, Noy N. Transthyretin blocks retinol uptake and cellsignaling by the holo-retinol-binding protein receptor STRA6. Molecular and cellular biology. 2012;32(19):3851-9.
9. Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. Journal of neurobiology. 2006;66(7):606-30.
10. D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011;3(1):63-103.
11. Blomhoff R, Holte K, Naess L, Berg T. Newly administered [3H] retinol is transferred from hepatocytes to stellate cells in liver for storage. Experimental cell research. 1984;150(1):186-93.
12. Shirakami Y, Lee S-A, Clugston RD, Blaner WS. Hepatic metabolism of retinoids and disease associations. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2012;1821(1):124-36.
13. von Reinersdorff D, Green MH, Green JB. Development of a compartmental model describing the dynamics of vitamin A metabolism in men. Advances in experimental medicine and biology. 1998;445:207-23.
14. Bellovino D, Apreda M, Gragnoli S, Massimi M, Gaetani S. Vitamin A transport: in vitro models for the study of RBP secretion. Molecular aspects of medicine. 2003;24(6):411-20.
15. Quadro L, Blaner WS, Salchow DJ, Vogel S, Piantedosi R, Gouras P, et al. Impaired retinal function and vitamin A availability in mice lacking retinol‐binding protein. The EMBO journal. 1999;18(17):4633-44.
16. Blomhoff R, Helgerud P, Rasmussen M, Berg T, Norum KR. In vivo uptake of chylomicron [3H]retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cells. Proceedings of the National Academy of Sciences of the United States of America. 1982;79(23):7326-30.
17. Flower DR, North AC, Sansom CE. The lipocalin protein family: structural and sequence overview. Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology. 2000;1482(1):9-24.
18. Salier JP, Åkerström B, Borregaard N, Flower DR. Lipocalins in bioscience: the first family gathering. Bioessays. 2004;26(4):456-8.
19. Newcomer M, Jones T, Aqvist J, Sundelin J, Eriksson U, Rask L, et al. The three-dimensional structure of retinol-binding protein. The EMBO journal. 1984;3(7):1451.
20. Noy N, Xu ZJ. Thermodynamic parameters of the binding of retinol to binding proteins and to membranes. Biochemistry. 1990;29(16):3888-92.
21. Berni R, Malpeli G, Folli C, Murrell JR, Liepnieks JJ, Benson MD. The Ile-84--> Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein. Journal of Biological Chemistry. 1994;269(38):23395-8.
22. Zanotti G, Malpeli G, Berni R. The interaction of N-ethyl retinamide with plasma retinol-binding protein (RBP) and the crystal structure of the retinoid-RBP complex at 1.9-A resolution. Journal of Biological Chemistry. 1993;268(33):24873-9.
23. Newcomer ME, Ong DE. Plasma retinol binding protein: structure and function of the prototypic lipocalin. Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology. 2000;1482(1):57-64.
24. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436(7049):356-62.
25. Graham TE, Yang Q, Blüher M, Hammarstedt A, Ciaraldi TP, Henry RR, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. New England Journal of Medicine. 2006;354(24):2552-63.
26. Kowalska I, Straczkowski M, Adamska A, Nikolajuk A, Karczewska-Kupczewska M, Otziomek E, et al. Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance. The Journal of Clinical Endocrinology & Metabolism. 2008;93(7):2786-9.
27. Mostafaie N, Sebesta C, Zehetmayer S, Jungwirth S, Huber KR, Hinterberger M, et al. Circulating retinol-binding protein 4 and metabolic syndrome in the elderly. Wiener Medizinische Wochenschrift. 2011;161(21-22):505-10.
28. Cheng J, Li Y, Wu G, Zheng J, Lu H, Shi X, et al. Ectopic expression of RBP4 impairs the insulin pathway and inguinal fat deposition in mice. Journal of physiology and biochemistry. 2014;70(2):479-86.
29. Ülgen F, Herder C, Kühn MC, Willenberg HS, Schott M, Scherbaum WA, et al. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Archives of physiology and biochemistry. 2010;116(2):57-62.
30. Henze A, Frey SK, Raila J, Tepel M, Scholze A, Pfeiffer AF, et al. Evidence that kidney function but not type 2 diabetes determines retinol-binding protein 4 serum levels. Diabetes. 2008;57(12):3323-6.
31. Akbay E, Muslu N, Nayır E, Ozhan O, Kiykim A. Serum retinol binding protein 4 level is related with renal functions in Type 2 diabetes. Journal of endocrinological investigation. 2010;33(10):725-9.
32. Taha C, Klip A. The insulin signaling pathway. Journal of Membrane Biology. 1999;169(1):1-12.
33. Ost A, Danielsson A, Liden M, Eriksson U, Nystrom FH, Stralfors P. Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2007;21(13):3696-704.
34. Mills JP, Furr HC, Tanumihardjo SA. Retinol to retinol-binding protein (RBP) is low in obese adults due to elevated apo-RBP. Experimental Biology and Medicine. 2008;233(10):1255-61.
35. Jia W, Wu H, Bao Y, Wang C, Lu J, Zhu J, et al. Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism. 2007;92(8):3224-9.
36. Janke J, Engeli S, Boschmann M, Adams F, Böhnke J, Luft FC, et al. Retinol-binding protein 4 in human obesity. Diabetes. 2006;55(10):2805-10.
37. Haider DG, Schindler K, Prager G, Bohdjalian A, Luger A, Wolzt M, et al. Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects. The Journal of Clinical Endocrinology & Metabolism. 2007;92(3):1168-71.
38. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. The Journal of Clinical Endocrinology & Metabolism. 2007;92(5):1971-4.
39. Barazzoni R, Zanetti M, Semolic A, Pirulli A, Cattin MR, Biolo G, et al. High plasma retinol binding protein 4 (RBP4) is associated with systemic inflammation independently of low RBP4 adipose expression and is normalized by transplantation in nonobese, nondiabetic patients with chronic kidney disease. Clinical endocrinology. 2011;75(1):56-63.
40. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation. 2003;112(12):1821.
41. Lumeng CN, DeYoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007;56(1):16-23.
42. Ando Y. [Transthyretin: it's miracle function and pathogenesis]. Rinsho byori The Japanese journal of clinical pathology. 2009;57(3):228-35.
43. Buxbaum JN, Reixach N. Transthyretin: the servant of many masters. Cellular and molecular life sciences. 2009;66(19):3095-101.
44. Blake C, Geisow M, Oatley S, Rerat B, Rerat C. Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 Å. Journal of molecular biology. 1978;121(3):339-56.
45. Zanotti G, Berni R, Monaco H. Crystal structure of liganded and unliganded forms of bovine plasma retinol-binding protein. Journal of Biological Chemistry. 1993;268(15):10728-38.
46. Selvaraj SR, Bhatia V, Tatu U. Oxidative folding and assembly with transthyretin are sequential events in the biogenesis of retinol binding protein in the endoplasmic reticulum. Molecular biology of the cell. 2008;19(12):5579-92.
47. Ghyselinck NB, Båvik C, Sapin V, Mark M, Bonnier D, Hindelang C, et al. Cellular retinol‐binding protein I is essential for vitamin A homeostasis. The EMBO journal. 1999;18(18):4903-14.
48. Naylor HM, Newcomer ME. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP. Biochemistry. 1999;38(9):2647-53.
49. Wei S, Episkopou V, Piantedosi R, Maeda S, Shimada K, Gottesman ME, et al. Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination. The Journal of biological chemistry. 1995;270(2):866-70.
50. Kawaguchi R, Yu J, Wiita P, Ter-Stepanian M, Sun H. Mapping the membrane topology and extracellular ligand binding domains of the retinol binding protein receptor. Biochemistry. 2008;47(19):5387-95.
51. Noy N. Reply to "Apo-RBP, Holo-RBP, and insulin resistance". Mol Cell Biol. 2014;34(11):2107.
52. Zhong M, Kawaguchi R, Kassai M, Sun H. Apo-RBP, holo-RBP, and insulin resistance. Mol Cell Biol. 2014;34(11):2105-6.
53. Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, et al. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 2007;315(5813):820-5.
54. Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, et al. RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell metabolism. 2008;7(3):258-68.
55. Ruiz A, Mark M, Jacobs H, Klopfenstein M, Hu J, Lloyd M, et al. Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Investigative ophthalmology & visual science. 2012;53(6):3027.
56. Zhong M, Kawaguchi R, Ter-Stepanian M, Kassai M, Sun H. Vitamin a transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding protein. 2013.
57. Quadro L, Hamberger L, Colantuoni V, Gottesman ME, Blaner WS. Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models. Molecular aspects of medicine. 2003;24(6):421-30.
58. Zhong M, Kawaguchi R, Kassai M, Sun H. Howfree retinol behaves differently from rbp-bound retinol in RBP receptor-mediated vitamin A uptake. Mol Cell Biol. 2014;34(11):2108-10.
59. Pasutto F, Sticht H, Hammersen G, Gillessen-Kaesbach G, FitzPatrick DR, Nürnberg G, et al. Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. The American Journal of Human Genetics. 2007;80(3):550-60.
60. Kawaguchi R, Yu J, Ter-Stepanian M, Zhong M, Cheng G, Yuan Q, et al. Receptor-mediated cellular uptake mechanism that couples to intracellular storage. ACS chemical biology. 2011;6(10):1041-51.
61. Kawaguchi R, Zhong M, Kassai M, Ter-Stepanian M, Sun H. STRA6-catalyzed vitamin A influx, efflux, and exchange. The Journal of membrane biology. 2012;245(11):731-45.
62. Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science. 1996;271(5248):518-20.
63. Connelly MA, Williams DL. Scavenger receptor BI: a scavenger receptor with a mission to transport high density lipoprotein lipids. Current opinion in lipidology. 2004;15(3):287-95.
64. Szeto W, Jiang W, Tice DA, Rubinfeld B, Hollingshead PG, Fong SE, et al. Overexpression of the retinoic acid-responsive gene STRA6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. Cancer research. 2001;61(10):4197-205.
65. O'Shea JJ, Gadina M, Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell. 2002;109(2):S121-S31.
66. Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity. Nature immunology. 2003;4(12):1169-76.
67. Croker BA, Kiu H, Nicholson SE, editors. SOCS regulation of the JAK/STAT signalling pathway. Seminars in cell & developmental biology; 2008: Elsevier.
68. Dentelli P, Trombetta A, Togliatto G, Zeoli A, Rosso A, Uberti B, et al. Formation of STAT5/PPARγ transcriptional complex modulates angiogenic cell bioavailability in diabetes. Arteriosclerosis, thrombosis, and vascular biology. 2009;29(1):114-20.
69. Noy N. Reply to "How free retinol behaves differently from RBP-bound retinol in RBP receptor-mediated vitamin A uptake". Mol Cell Biol. 2014;34(11):2111-2.
70. Felding P, Fex G. Cellular origin of prealbumin in the rat. Biochimica et Biophysica Acta (BBA)-General Subjects. 1982;716(3):446-9.
71. Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma J-x. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase-and nuclear factor kappa B-dependent and retinol-independent mechanism. Molecular and cellular biology. 2012;32(24):5103-15.
72. Alapatt P, Guo F, Komanetsky SM, Wang S, Cai J, Sargsyan A, et al. Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). Journal of Biological Chemistry. 2013;288(2):1250-65
2. Evans R. The molecular basis of signaling by vitamin A and its metabolites. Harvey lectures. 1994;90:105.
3. Wongsiriroj N, Piantedosi R, Palczewski K, Goldberg IJ, Johnston TP, Li E, et al. The molecular basis of retinoid absorption: a genetic dissection. The Journal of biological chemistry. 2008;283(20):13510-9.
4. Soprano DR, Soprano KJ, Goodman DS. Retinol-binding protein messenger RNA levels in the liver and in extrahepatic tissues of the rat. Journal of lipid research. 1986;27(2):166-71.
5. Berry DC, Jin H, Majumdar A, Noy N. Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. Proceedings of the National Academy of Sciences. 2011;108(11):4340-5.
6. Berry DC, Noy N. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2012;1821(1):168-76.
7. Berry DC, O'Byrne SM, Vreeland AC, Blaner WS, Noy N. Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6. Molecular and cellular biology. 2012;32(15):3164-75.
8. Berry DC, Croniger CM, Ghyselinck NB, Noy N. Transthyretin blocks retinol uptake and cellsignaling by the holo-retinol-binding protein receptor STRA6. Molecular and cellular biology. 2012;32(19):3851-9.
9. Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. Journal of neurobiology. 2006;66(7):606-30.
10. D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011;3(1):63-103.
11. Blomhoff R, Holte K, Naess L, Berg T. Newly administered [3H] retinol is transferred from hepatocytes to stellate cells in liver for storage. Experimental cell research. 1984;150(1):186-93.
12. Shirakami Y, Lee S-A, Clugston RD, Blaner WS. Hepatic metabolism of retinoids and disease associations. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2012;1821(1):124-36.
13. von Reinersdorff D, Green MH, Green JB. Development of a compartmental model describing the dynamics of vitamin A metabolism in men. Advances in experimental medicine and biology. 1998;445:207-23.
14. Bellovino D, Apreda M, Gragnoli S, Massimi M, Gaetani S. Vitamin A transport: in vitro models for the study of RBP secretion. Molecular aspects of medicine. 2003;24(6):411-20.
15. Quadro L, Blaner WS, Salchow DJ, Vogel S, Piantedosi R, Gouras P, et al. Impaired retinal function and vitamin A availability in mice lacking retinol‐binding protein. The EMBO journal. 1999;18(17):4633-44.
16. Blomhoff R, Helgerud P, Rasmussen M, Berg T, Norum KR. In vivo uptake of chylomicron [3H]retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cells. Proceedings of the National Academy of Sciences of the United States of America. 1982;79(23):7326-30.
17. Flower DR, North AC, Sansom CE. The lipocalin protein family: structural and sequence overview. Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology. 2000;1482(1):9-24.
18. Salier JP, Åkerström B, Borregaard N, Flower DR. Lipocalins in bioscience: the first family gathering. Bioessays. 2004;26(4):456-8.
19. Newcomer M, Jones T, Aqvist J, Sundelin J, Eriksson U, Rask L, et al. The three-dimensional structure of retinol-binding protein. The EMBO journal. 1984;3(7):1451.
20. Noy N, Xu ZJ. Thermodynamic parameters of the binding of retinol to binding proteins and to membranes. Biochemistry. 1990;29(16):3888-92.
21. Berni R, Malpeli G, Folli C, Murrell JR, Liepnieks JJ, Benson MD. The Ile-84--> Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein. Journal of Biological Chemistry. 1994;269(38):23395-8.
22. Zanotti G, Malpeli G, Berni R. The interaction of N-ethyl retinamide with plasma retinol-binding protein (RBP) and the crystal structure of the retinoid-RBP complex at 1.9-A resolution. Journal of Biological Chemistry. 1993;268(33):24873-9.
23. Newcomer ME, Ong DE. Plasma retinol binding protein: structure and function of the prototypic lipocalin. Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology. 2000;1482(1):57-64.
24. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436(7049):356-62.
25. Graham TE, Yang Q, Blüher M, Hammarstedt A, Ciaraldi TP, Henry RR, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. New England Journal of Medicine. 2006;354(24):2552-63.
26. Kowalska I, Straczkowski M, Adamska A, Nikolajuk A, Karczewska-Kupczewska M, Otziomek E, et al. Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance. The Journal of Clinical Endocrinology & Metabolism. 2008;93(7):2786-9.
27. Mostafaie N, Sebesta C, Zehetmayer S, Jungwirth S, Huber KR, Hinterberger M, et al. Circulating retinol-binding protein 4 and metabolic syndrome in the elderly. Wiener Medizinische Wochenschrift. 2011;161(21-22):505-10.
28. Cheng J, Li Y, Wu G, Zheng J, Lu H, Shi X, et al. Ectopic expression of RBP4 impairs the insulin pathway and inguinal fat deposition in mice. Journal of physiology and biochemistry. 2014;70(2):479-86.
29. Ülgen F, Herder C, Kühn MC, Willenberg HS, Schott M, Scherbaum WA, et al. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Archives of physiology and biochemistry. 2010;116(2):57-62.
30. Henze A, Frey SK, Raila J, Tepel M, Scholze A, Pfeiffer AF, et al. Evidence that kidney function but not type 2 diabetes determines retinol-binding protein 4 serum levels. Diabetes. 2008;57(12):3323-6.
31. Akbay E, Muslu N, Nayır E, Ozhan O, Kiykim A. Serum retinol binding protein 4 level is related with renal functions in Type 2 diabetes. Journal of endocrinological investigation. 2010;33(10):725-9.
32. Taha C, Klip A. The insulin signaling pathway. Journal of Membrane Biology. 1999;169(1):1-12.
33. Ost A, Danielsson A, Liden M, Eriksson U, Nystrom FH, Stralfors P. Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2007;21(13):3696-704.
34. Mills JP, Furr HC, Tanumihardjo SA. Retinol to retinol-binding protein (RBP) is low in obese adults due to elevated apo-RBP. Experimental Biology and Medicine. 2008;233(10):1255-61.
35. Jia W, Wu H, Bao Y, Wang C, Lu J, Zhu J, et al. Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism. 2007;92(8):3224-9.
36. Janke J, Engeli S, Boschmann M, Adams F, Böhnke J, Luft FC, et al. Retinol-binding protein 4 in human obesity. Diabetes. 2006;55(10):2805-10.
37. Haider DG, Schindler K, Prager G, Bohdjalian A, Luger A, Wolzt M, et al. Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects. The Journal of Clinical Endocrinology & Metabolism. 2007;92(3):1168-71.
38. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. The Journal of Clinical Endocrinology & Metabolism. 2007;92(5):1971-4.
39. Barazzoni R, Zanetti M, Semolic A, Pirulli A, Cattin MR, Biolo G, et al. High plasma retinol binding protein 4 (RBP4) is associated with systemic inflammation independently of low RBP4 adipose expression and is normalized by transplantation in nonobese, nondiabetic patients with chronic kidney disease. Clinical endocrinology. 2011;75(1):56-63.
40. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation. 2003;112(12):1821.
41. Lumeng CN, DeYoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007;56(1):16-23.
42. Ando Y. [Transthyretin: it's miracle function and pathogenesis]. Rinsho byori The Japanese journal of clinical pathology. 2009;57(3):228-35.
43. Buxbaum JN, Reixach N. Transthyretin: the servant of many masters. Cellular and molecular life sciences. 2009;66(19):3095-101.
44. Blake C, Geisow M, Oatley S, Rerat B, Rerat C. Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 Å. Journal of molecular biology. 1978;121(3):339-56.
45. Zanotti G, Berni R, Monaco H. Crystal structure of liganded and unliganded forms of bovine plasma retinol-binding protein. Journal of Biological Chemistry. 1993;268(15):10728-38.
46. Selvaraj SR, Bhatia V, Tatu U. Oxidative folding and assembly with transthyretin are sequential events in the biogenesis of retinol binding protein in the endoplasmic reticulum. Molecular biology of the cell. 2008;19(12):5579-92.
47. Ghyselinck NB, Båvik C, Sapin V, Mark M, Bonnier D, Hindelang C, et al. Cellular retinol‐binding protein I is essential for vitamin A homeostasis. The EMBO journal. 1999;18(18):4903-14.
48. Naylor HM, Newcomer ME. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP. Biochemistry. 1999;38(9):2647-53.
49. Wei S, Episkopou V, Piantedosi R, Maeda S, Shimada K, Gottesman ME, et al. Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination. The Journal of biological chemistry. 1995;270(2):866-70.
50. Kawaguchi R, Yu J, Wiita P, Ter-Stepanian M, Sun H. Mapping the membrane topology and extracellular ligand binding domains of the retinol binding protein receptor. Biochemistry. 2008;47(19):5387-95.
51. Noy N. Reply to "Apo-RBP, Holo-RBP, and insulin resistance". Mol Cell Biol. 2014;34(11):2107.
52. Zhong M, Kawaguchi R, Kassai M, Sun H. Apo-RBP, holo-RBP, and insulin resistance. Mol Cell Biol. 2014;34(11):2105-6.
53. Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, et al. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 2007;315(5813):820-5.
54. Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, et al. RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell metabolism. 2008;7(3):258-68.
55. Ruiz A, Mark M, Jacobs H, Klopfenstein M, Hu J, Lloyd M, et al. Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Investigative ophthalmology & visual science. 2012;53(6):3027.
56. Zhong M, Kawaguchi R, Ter-Stepanian M, Kassai M, Sun H. Vitamin a transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding protein. 2013.
57. Quadro L, Hamberger L, Colantuoni V, Gottesman ME, Blaner WS. Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models. Molecular aspects of medicine. 2003;24(6):421-30.
58. Zhong M, Kawaguchi R, Kassai M, Sun H. Howfree retinol behaves differently from rbp-bound retinol in RBP receptor-mediated vitamin A uptake. Mol Cell Biol. 2014;34(11):2108-10.
59. Pasutto F, Sticht H, Hammersen G, Gillessen-Kaesbach G, FitzPatrick DR, Nürnberg G, et al. Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. The American Journal of Human Genetics. 2007;80(3):550-60.
60. Kawaguchi R, Yu J, Ter-Stepanian M, Zhong M, Cheng G, Yuan Q, et al. Receptor-mediated cellular uptake mechanism that couples to intracellular storage. ACS chemical biology. 2011;6(10):1041-51.
61. Kawaguchi R, Zhong M, Kassai M, Ter-Stepanian M, Sun H. STRA6-catalyzed vitamin A influx, efflux, and exchange. The Journal of membrane biology. 2012;245(11):731-45.
62. Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science. 1996;271(5248):518-20.
63. Connelly MA, Williams DL. Scavenger receptor BI: a scavenger receptor with a mission to transport high density lipoprotein lipids. Current opinion in lipidology. 2004;15(3):287-95.
64. Szeto W, Jiang W, Tice DA, Rubinfeld B, Hollingshead PG, Fong SE, et al. Overexpression of the retinoic acid-responsive gene STRA6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. Cancer research. 2001;61(10):4197-205.
65. O'Shea JJ, Gadina M, Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell. 2002;109(2):S121-S31.
66. Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity. Nature immunology. 2003;4(12):1169-76.
67. Croker BA, Kiu H, Nicholson SE, editors. SOCS regulation of the JAK/STAT signalling pathway. Seminars in cell & developmental biology; 2008: Elsevier.
68. Dentelli P, Trombetta A, Togliatto G, Zeoli A, Rosso A, Uberti B, et al. Formation of STAT5/PPARγ transcriptional complex modulates angiogenic cell bioavailability in diabetes. Arteriosclerosis, thrombosis, and vascular biology. 2009;29(1):114-20.
69. Noy N. Reply to "How free retinol behaves differently from RBP-bound retinol in RBP receptor-mediated vitamin A uptake". Mol Cell Biol. 2014;34(11):2111-2.
70. Felding P, Fex G. Cellular origin of prealbumin in the rat. Biochimica et Biophysica Acta (BBA)-General Subjects. 1982;716(3):446-9.
71. Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma J-x. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase-and nuclear factor kappa B-dependent and retinol-independent mechanism. Molecular and cellular biology. 2012;32(24):5103-15.
72. Alapatt P, Guo F, Komanetsky SM, Wang S, Cai J, Sargsyan A, et al. Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). Journal of Biological Chemistry. 2013;288(2):1250-65
| Files | ||
| Issue | Vol 2, No 2 (Spring 2016) | |
| Section | Review Article(s) | |
| Keywords | ||
| Retinol binding protein 4 RBP4 Retinol insulin resistance STRA6 Inflammation transthyretin | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Mohamadpour Z, Zabetian-Targhi F, Mahmoudi M. Association of retinol binding protein 4 and insulin resistance: a review on molecular mechanisms. J Nutr Sci & Diet. 2016;2(2).
