Journal of Nutritional Sciences and Dietetics 2016. 2(3):.

Comparison of serum Total Antioxidant Capacity between metabolic syndrome patients and non-metabolic syndrome people with normal or high BMI
Atefeh Hasaninasab, Alireza Esteghamati, Kamal Azam, Somaye Yosaee, Nahal Habibi, Kurosh Djafarian



Background/Objective: Increased visceral fat and changes in lipid profile, insulin resistance, and impaired glucose tolerance affected by oxidative stress can subsequently cause changes in serum total antioxidant capacity. This study aimed to determine the differences in plasma total antioxidant capacity between metabolic syndrome patients and those without metabolic syndrome with normal weight, overweight and obesity.

Subjects and methods: A case-control study was carried out among 146 men and women (aged 20-55 years) in Endocrinology Center of Tehran University of Medical Sciences. The case group included overweight/obese subjects with metabolic syndrome and the two control groups were weight-matched subjects without metabolic syndrome and normal weight subjects without metabolic syndrome. Total antioxidant capacity was determined using colorimetric method.

Results: Waist circumference and total antioxidant capacity of case group were significantly higher than that of both control groups ((p<0.001) for both). There was no significant difference between normal and overweight/obese control groups in total antioxidant capacity level (p=0.53).

Conclusion: Oxidative stress presumably is an important factor in pathology of metabolic syndrome and total antioxidant capacity may be responsible for defense against oxidants.


BMI, metabolic syndrome, oxidative stress, total antioxidant capacity


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