Journal of Nutritional Sciences and Dietetics 2016. 2(1):.

Brain-derived neurotrophic factor (BDNF) is increased by omega-3 fatty acids in coronary artery disease: a randomized, double-blind, placebo-controlled
Fahime Agh, Niyaz Mohammadzadeh Honarvar, Mahmoud Djalali, Ebrahim Nematipour, Mahnaz Zarei, Shirin Jafari Salim, Simin Samavat, Mohammad Hassan Javanbakht


Background: Cardiovascular disease is the most common cause of morbidity and mortality throughout the world. Diminution of brain-derived neurotrophic factor (BDNF) plays a chief role in the pathogenesis of coronary artery disease (CAD). One of the beneficial effects of omega-3 fatty acids is to modulate the secretion of BDNF. We aimed to evaluate the effects of omega-3 fatty acids supplementation on serum BDNF in men with CAD.

Methods: Forty-eight CAD patients were randomly assigned to either the omega-3 (n=24) or placebo (n=24) group. In the omega-3 group each subject received 4 omega-3 soft gels per day (720 mg eicosapentaenoic acid plus 480 mg docosahexaenoic acid), while each subject in the placebo group received 4 placebo soft gels (edible paraffin) for a period of 8 weeks. Serum BDNF, high-sensitivity C-reactive protein (hs-CRP), serum lipoproteins, anthropometric indices, body composition, food intake and physical activity were evaluated before and after intervention.

Results: Omega-3 fatty acids supplementation increased serum BDNF (p= 0.015), and did not cause significant modifications on the blood pressure, serum lipids with the exception of LDL, fasting blood glucose, anthropometric measurements and body composition (p > 0.05).

Conclusion: Omega-3 fatty acids supplementation significantly enhances serum BDNF in male patients who have CAD.


Omega-3 fatty acids, Eicosapentaenoic acid, Docosahexaenoic acid, Coronary artery disease, Brain-derived neurotrophic factor

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