Review Article

Maternal 25-hydroxyvitamin D level and postpartum depression: a systematic review

Abstract

Background: To evaluate systematically the role of maternal vitamin D levels in postpartum depression (PPD)
Methods: PubMed and EMBASE databases were searched using the search words [vitamin D, cholecalciferol, calcitriol, 1,25 (OH)D] in combination with [postpartum depression, PPD, postnatal depression, PND] in the title, abstract, and keywords. The search was limited to publications in English. Criteria for inclusion in this systematic review were data on maternal 25(OH) D and PPD.
Results: We identified 147 publications at first, from which five observational studies were selected for inclusion in the final review.in one study 25(OH) D was associated with PPD. In another one was found an association but in category with vitamin D lower than 47 nMol/L was significant in p<0.05. In two studies the blood sample was taken after childbirth and observed an increased risk of PPD associated with only serum 25[OH] D levels ≤ 25.46 nmol/L and ≤25 nmol/L and in one studies not only observed no association between vitamin D concentrations and risk of PPD  but also found that in compare with  women 50–79 nmol/L, women with higher 25(OH)D3 concentrations (79 nmol/L) appeared to have significantly increased risks of PPD.
Conclusion: It seems that vitamin D plays a role along with other factors that might cause postpartum depression, in a specific but unknown cut off. Further studies are necessary to identify the exact role of vitamin D on PPD.

Lopez AD, Mathers CD, Ezzati M, Jamison DT,Murray CJ. Global and regional burden ofdisease and risk factors, 2001: systematicanalysis of population health data. The Lancet.2006;367(9524):1747-57.

Almond P. Postnatal depression: a global publichealth perspective. Perspect Public Health.2009;129(5):221-7.

Gress-Smith JL, Luecken LJ, Lemery-ChalfantK, Howe R. Postpartum depression prevalenceand impact on infant health, weight, and sleep inlow-income and ethnic minority women andinfants. Matern Child Health J. 2012;16(4):887-93.

Parsons CE, Young KS, Rochat TJ, KringelbachM, Stein A. Postnatal depression and its effectson child development: a review of evidence fromlow-and middle-income countries. Br Med Bull.2012;101(1).

Dennis C-L, McQueen K. The relationshipbetween infant-feeding outcomes and postpartumdepression: a qualitative systematic review.Pediatrics. 2009;123(4):e736-e51.

Flykt M, Kanninen K, Sinkkonen J, PunamäkiRL. Maternal depression and dyadic interaction:the role of maternal attachment style. InfantChild Dev. 2010;19(5):530-50.

Cadzow SP, Armstrong KL, Fraser JA. Stressedparents with infants: reassessing physical abuserisk factors. Child Abuse Negl. 1999; 23(9):845-53.

Goodman SH, Rouse MH, Connell AM, BrothMR, Hall CM, Heyward D. Maternal depressionand child psychopathology: a meta-analyticreview. Clin Child Fam Psychol Rev.2011;14(1):1-27.

Brand SR, Brennan PA. Impact of antenatal andpostpartum maternal mental illness: how are thechildren? Clin Obstet Gynecol. 2009;52(3):441-55.

Krishnan V, Nestler EJ. Linking molecules tomood: new insight into the biology of depression.Am J Psychiatry.2010;167(11):305-20.

Eyles DW, Smith S, Kinobe R, Hewison M,McGrath JJ. Distribution of the vitamin Dreceptor and 1α-hydroxylase in human brain. JChem Neuroanat. 2005; 29(1):21-30.

de Abreu DF, Eyles D, Feron F. Vitamin D, aneuro-immunomodulator: implications forneurodegenerative and autoimmune diseases.Psychoneuroendocrinology. 2009;34:S265-S77.

Ginde AA, Liu MC, Camargo CA. Demographicdifferences and trends of vitamin D insufficiencyin the US population, 1988-2004. Arch InternMed. 2009;169(6):626-32.

Holick MF. Vitamin D deficiency. N Engl J Med.2007;2007(357):266-81.

May HT, Bair TL, Lappé DL, Anderson JL,Horne BD, Carlquist JF, et al. Association ofvitamin D levels with incident depression amonga general cardiovascular population. Am Heart J.2010;159(6):1037-43.

Chan R, Chan D, Woo J, Ohlsson C, MellströmD, Kwok T, et al. Association between serum 25-hydroxyvitamin D and psychological health inolder Chinese men in a cohort study. J AffectDisord. 2011;130(1):251-9.

Pan A, Lu L, Franco OH, Yu Z, Li H, Lin X.Association between depressive symptoms and25-hydroxyvitamin D in middle-aged and elderlyChinese. J Affect Disord. 2009;118(1):240-3.

Gur EB, Gokduman A, Turan GA, Tatar S,Hepyilmaz I, Zengin EB, et al. Mid-pregnancyvitamin D levels and postpartum depression. EurJ Obstet Gynecol Reprod Biol. 2014;179:110-6.

Robinson M, Whitehouse AJ, Newnham JP,Gorman S, Jacoby P, Holt BJ, et al. Lowmaternal serum vitamin D during pregnancy andthe risk for postpartum depression symptoms.Arch Womens Ment Health. 2014;17(3):213-9.

Gould JF, Anderson AJ, Yelland LN, SmithersLG, Skeaff CM, Gibson RA, et al. Association ofcord blood vitamin D at delivery with postpartumdepression in Australian women. Aust N Z JObstet Gynaecol. 2015;55(5):446-52.

Fu CW, Liu JT, Tu WJ, Yang JQ, Cao Y.Association between serum 25‐hydroxyvitaminD levels measured 24 hours after delivery andpostpartum depression. BJOG. 2015;122(12):1688-94.

Vigod SN, Villegas L, Dennis CL, Ross LE.Prevalence and risk factors for postpartumdepression among women with preterm and lowbirth‐weight infants: a systematic review. BJOG.2010;117(5):540-50.

Dindar I, Erdogan S. Screening of Turkishwomen for postpartum depression within the firstpostpartum year: the risk profile of a communitysample. Public Health Nurs. 2007;24(2):176-83.

Garland CF, Garland FC, Gorham ED, Lipkin M,Newmark H, Mohr SB, et al. The role of vitamin D in cancer prevention. Am J Public Health.2006;96(2):252-61.

Newmark HL, Newmark J. Vitamin D andParkinson's disease—a hypothesis. Mov Disord.2007;22(4):461-8.

Nielsen NO, Strøm M, Boyd HA, Andersen EW,Wohlfahrt J, Lundqvist M, et al. Vitamin D status during pregnancy and the risk of subsequentpostpartum depression: a case-control study.PloS One. 2013;8(11):e80686.

Wang T-T, Tavera-Mendoza LE, Laperriere D,Libby E, Burton MacLeod N, Nagai Y, et al.Large-scale in silico and microarraybasedidentification of direct 1, 25-dihydroxyvitaminD3 target genes. Mol Endocrinol.2005;19(11):2685-95.

Buell JS, Dawson-Hughes B. Vitamin D andneurocognitive dysfunction: preventing “D”ecline? Mol Aspects Med. 2008;29(6):415-22.

Bertone-Johnson ER. Vitamin D and theoccurrence of depression: causal association orcircumstantial evidence? Nutr Rev.2009;67(8):481-92.

Anglin RE, Samaan Z, Walter SD, McDonaldSD. Vitamin D deficiency and depression inadults: systematic review and metaanalysis. Br JPsychiatry. 2013;202(2):100-7.

Files
IssueVol 2, No 1 (Winter 2016) QRcode
SectionReview Article(s)
Published2016-01-29
Keywords
Vitamin D postpartum depression pregnancy meta-analysis

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Kazemi S, Djafarian K, Shab-Bidar S, Aghaei E. Maternal 25-hydroxyvitamin D level and postpartum depression: a systematic review. J Nutr Sci & Diet. 2(1):43-49.