Original Article

The Effects of vitamin D supplementation on lipid and inflammatory profile of healthy adolescent boys

A randomized controlled trial


Background: Deficiency of Vitamin D, an anti-inflammatory micronutrient with some favorable effects on lipid profiles, has been found to be highly prevalent in adolescents. We aimed to investigate the effect of a high-dose vitamin D supplementation on the lipid and inflammatory profiles of healthy adolescent boys.

Methods: In this randomized double-blind placebo-controlled trial, sixty healthy adolescent boys (age 17 yr) were recruited from one high school in Tehran, Iran and randomly assigned to two groups. The supplement group received vitamin D pearls at a dose of 50,000 IU monthly for 6 months and the other group was given placebo pearls for the same duration. Before and after the treatment, the serum levels of 25-hydroxy vitamin D (25(OH) D), parathyroid hormone (PTH), retinol, lead (Pb), the lipid profile and inflammatory biomarkers were measured and compared.

Results: Between groups statistical analysis showed that a high dose (50,000 IU/month) vitamin D significantly increased and decreased serum levels of vitaamin D and PTH, respectively (P < 0.05). No significant change was observed in serum levels of retinol and Pb. Between-group analysis revealed that the serum levels of TG and HDL decreased and increased, respectively (P < 0.05). Both the within- and between-group analysis showed that serum tumor necrosis factor receptor 2 (TNFR2) concentration declined while serum interleukin-10 (IL-10) increased in response to vitamin D supplementation (P < 0.05).

Conclusion: A high dose (50,000 IU/month) Vitamin D supplement seems to have some positive impact on serum vitamin D, lipid profile and inflammatory biomarkers in healthy adolescent boys.

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IssueVol 5, No 2 (Spring 2019) QRcode
SectionOriginal Article(s)
Key words: Vitamin D Adolescent Inflammation Lipid profile PTH

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How to Cite
Yarparvar A. The Effects of vitamin D supplementation on lipid and inflammatory profile of healthy adolescent boys. J Nutr Sci & Diet. 5(2).