Adherence to Mediterranean dietary pattern and risk of breast and endometrial Cancers: a systematic review
Breast and endometrial cancer (EC) is the most prevalent cancers among women all over the world and Breast cancer (BC) is rated as the first cause of mortality among other cancers in women. Major known risk factors for breast and endometrial cancers are obesity, low physical activity, and unhealthy and poor quality diet that contribute to about 30-35% of cancer incidence. Recent evidence support that adherence to a healthy dietary pattern such as the Mediterranean diet has been associated with reduced risk of all types of cancers including breast and endometrial. Data of the current review were identified through a systematic search of PubMed, Scopus, and Cochrane databases and also selected articles references by using the following search terms/keywords: “Mediterranean diet”, “Mediterranean dietary pattern”, breast, mammary, endometrial, cancer, carcinoma, and neoplasm. Through the review process, eight case-controls, four cohorts, and one clinical trial were identified. Included studies were conducted among post and pre-menopausal women in the United States of America, and some European countries. The review suggests the protective role of the Mediterranean diet against BC risk in both pre and post-menopausal stage. According to the fact that there were insufficient researches on the association between MD pattern and endometrial cancer risk, its protective effect cannot be interpreted with certainty. Further studies in this area especially interventional studies are needed to determine the causality.
2. Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. International journal of cancer. 2013;132(5):1133-45.
3. Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, et al. Cancer is a preventable disease that requires major lifestyle changes. Pharmaceutical research. 2008;25(9):2097-116.
4. George SM, Ballard R, Shikany JM, Crane TE, Neuhouser ML. A prospective analysis of diet quality and endometrial cancer among 84,415 postmenopausal women in the Women's Health Initiative. Annals of epidemiology. 2015;25(10):788-93.
5. Toledo E, Salas-Salvado J, Donat-Vargas C, Buil-Cosiales P, Estruch R, Ros E, et al. Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. JAMA internal medicine. 2015;175(11):1752-60.
6. Trichopoulou A, Kouris-Blazos A, Wahlqvist ML, Gnardellis C, Lagiou P, Polychronopoulos E, et al. Diet and overall survival in elderly people. BMJ (Clinical research ed). 1995;311(7018):1457-60.
7. Mourouti N, Kontogianni MD, Papavagelis C, Plytzanopoulou P, Vassilakou T, Malamos N, et al. Adherence to the Mediterranean diet is associated with lower likelihood of breast cancer: a case-control study. Nutrition and cancer. 2014;66(5):810-7.
8. Castello A, Pollan M, Buijsse B, Ruiz A, Casas AM, Baena-Canada JM, et al. Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case-control EpiGEICAM study. British journal of cancer. 2014;111(7):1454-62.
9. Demetriou CA, Hadjisavvas A, Loizidou MA, Loucaides G, Neophytou I, Sieri S, et al. The mediterranean dietary pattern and breast cancer risk in Greek-Cypriot women: a case-control study. BMC cancer. 2012;12:113.
10. Murtaugh MA, Sweeney C, Giuliano AR, Herrick JS, Hines L, Byers T, et al. Diet patterns and breast cancer risk in Hispanic and non-Hispanic white women: the Four-Corners Breast Cancer Study. The American journal of clinical nutrition. 2008;87(4):978-84.
11. Buckland G, Travier N, Cottet V, Gonzalez CA, Lujan-Barroso L, Agudo A, et al. Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study. International journal of cancer. 2013;132(12):2918-27.
12. Couto E, Sandin S, Lof M, Ursin G, Adami HO, Weiderpass E. Mediterranean dietary pattern and risk of breast cancer. PloS one. 2013;8(2):e55374.
13. Castello A, Boldo E, Perez-Gomez B, Lope V, Altzibar JM, Martin V, et al. Adherence to the Western, Prudent and Mediterranean dietary patterns and breast cancer risk: MCC-Spain study. Maturitas. 2017;103:8-15.
14. Dalvi TB, Canchola AJ, Horn-Ross PL. Dietary patterns, Mediterranean diet, and endometrial cancer risk. Cancer causes & control : CCC. 2007;18(9):957-66.
15. Cade JE, Taylor EF, Burley VJ, Greenwood DC. Does the Mediterranean dietary pattern or the Healthy Diet Index influence the risk of breast cancer in a large British cohort of women? European journal of clinical nutrition. 2011;65(8):920-8.
16. Higgins J, Green S. Cochrane handbook for systematic reviews of interventions (Vol. 5): Wiley Online Library. 2008.
17. Turati F, Carioli G, Bravi F. Mediterranean Diet and Breast Cancer Risk. 2018;10(3).
18. Ricceri F, Giraudo MT, Fasanelli F, Milanese D, Sciannameo V, Fiorini L, et al. Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk. 2017;17(1):757.
19. Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. Journal of the American College of Cardiology. 2004;44(1):152-8.
20. Esposito K, Ciotola M, Giugliano D. Mediterranean diet, endothelial function and vascular inflammatory markers. Public health nutrition. 2006;9(8a):1073-6.
21. Panagiotakos DB, Dimakopoulou K, Katsouyanni K, Bellander T, Grau M, Koenig W, et al. Mediterranean diet and inflammatory response in myocardial infarction survivors. International journal of epidemiology. 2009;38(3):856-66.
22. Nunez-Cordoba JM, Valencia-Serrano F, Toledo E, Alonso A, Martinez-Gonzalez MA. The Mediterranean diet and incidence of hypertension: the Seguimiento Universidad de Navarra (SUN) Study. American journal of epidemiology. 2009;169(3):339-46.
23. Verberne L, Bach-Faig A, Buckland G, Serra-Majem L. Association between the Mediterranean diet and cancer risk: a review of observational studies. Nutrition and cancer. 2010;62(7):860-70.
24. Mitjavila MT, Fandos M, Salas-Salvado J, Covas MI, Borrego S, Estruch R, et al. The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial. Clinical nutrition (Edinburgh, Scotland). 2013;32(2):172-8.
25. Visioli F, Grande S, Bogani P, Galli C. The role of antioxidants in the mediterranean diets: focus on cancer. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2004;13(4):337-43.
26. Wu AH, Yu MC, Tseng CC, Stanczyk FZ, Pike MC. Dietary patterns and breast cancer risk in Asian American women. The American journal of clinical nutrition. 2009;89(4):1145-54.
27. Colditz GA, Rosner BA, Chen WY, Holmes MD, Hankinson SE. Risk factors for breast cancer according to estrogen and progesterone receptor status. Journal of the National Cancer Institute. 2004;96(3):218-28.
28. Carruba G, Granata OM, Pala V, Campisi I, Agostara B, Cusimano R, et al. A traditional Mediterranean diet decreases endogenous estrogens in healthy postmenopausal women. Nutrition and cancer. 2006;56(2):253-9.
29. Filomeno M, Bosetti C, Bidoli E, Levi F, Serraino D, Montella M, et al. Mediterranean diet and risk of endometrial cancer: a pooled analysis of three Italian case-control studies. British journal of cancer. 2015;112(11):1816-21.
30. Xu WH, Dai Q, Xiang YB, Zhao GM, Ruan ZX, Cheng JR, et al. Nutritional factors in relation to endometrial cancer: a report from a population-based case-control study in Shanghai, China. International journal of cancer. 2007;120(8):1776-81.
Copyright (c) 2019 Journal of Nutritional Sciences and Dietetics
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.