Effects of natural honey intake on glycaemic control and lipid profile in type 2 diabetes
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Abstract
Background: Natural honey is among products that are very rich in antioxidants.Several studies have demonstrated its advantages for human beings. However,diabetic patients are recommended not to consume a great amount because of itshigh content in sugar. The aim of the current study was to investigate the safety ofnatural honey in type 2 diabetes.
Methods: Thirty-three patients with type 2 diabetes were randomly recruited andate 10g of natural honey with water per day during ten weeks. During the studyperiod, they did not undergo any changes in their diet, drugs and lifestyle. Beforethe onset of the study and at the end, lipids, glycemic profile, and HbA1c weremeasured. The patients performed regularly capillary blood glucose monitoringtoo.
Results: We observed that HbA1c has significantly increased from 7.2% to 7.65%(p<10-5). Preprandial glycaemia has also increased, but not significantly.However, fasting and postprandial glycemias remained unchanged. Contrary toglycemic effects, honey improves lipid profile, but not significantly. Actually, totalcholesterol, triglycerides and LDL cholesterol have decreased, and HDLcholesterol has increased.
Conclusion: Daily consumption of Natural honey can deteriorate glycemic controlof diabetics. However, it is still much better than other sweeteners. So, diabeticsshould take precautions if they consume honey for its advantages, and they coulduse low doses of honey, less than 10 g per day. Nevertheless, more studies shouldbe done to investigate if honey can be beneficial and to determine the mechanismby which it can be
Kharroubi AT, Darwish HM. Diabetes mellitus:The epidemic of the century. World J Diabetes.2015; 25 (6): 850–867.
Roglic G, Unwin N. Mortality attributable todiabetes: estimates for the year 2010. DiabetesRes Clin Pract.2010; 87(1):15-19.
Shikata K, Ninomiya T, Kiyohara Y. Diabetesmellitus and cancer risk: review of theepidemiological evidence. Cancer Sci. 2013;104(1):9-14.
Jafari Anarkooli I, Barzegar Ganji H, PourheidarM. The protective effects of insulin and naturalhoney against hippocampal cell death instreptozotocin-induced diabetic rats. J DiabetesRes. 2014; 491571.
Balasubramanian K, Sivashanmugam P,Thameemdheen S, Govindarajulu P. Effect ofdiabetes mellitus on epididymal enzymes of adultrats. In dian J Exp Bio. 1991; 29 (10): 907-9.
Agarwal A, Prabakaran SA, Said TM. Preventionof oxidative stress injury to sperm. J Androl.2005; 26 (6): 654-60.
Gheldof N, Wang XH, Engeseth NJ.Identification and quantification of antioxidantcomponents of honeys from various floralsources. J Agric Food Chem. 2002; 50 (21):5870-7.
Eteraf-Oskouei T, Shaseb E, Ghaffary S, NajafiM. Prolonged preconditioning with naturalhoney against myocardial infarction injuries. PakJ Pharm Sci. 2013; 26 (4): 681-6.
Vaez H, Samadzadeh M, Zahednezhad F, NajafiM. Resistance to reperfusion injury followingterm post schemic administration of naturalhoney in globally ischemic isolated rat heart.Adv Pharm Bull. 2012; 2 (2): 189-96.
Najafi M, Zahednezhad F, Samadzadeh M, VaezH. Zero flow global ischemia induced injuries inrat heart are attenuated by natural honey. AdvPharm Bull. 2012; 2 (2): 165-71.
Batumalaie K, Zaman Safi S, Mohd YusofK, Shah Ismail I, Devi Sekaran S, Qvist R. Effectof gelam honey on the oxidative stress-inducedsignaling pathways in pancreatic hamster cells.Int J Endocrinol. 2013; 367312.
Mohamed M, Sirajudeen K, Swamy M, YaacobNS, Sulaiman SA. Studies on the antioxidantproperties of Tualang honey of Malaysia. Afr JTradit Complement Altern Med. 2009; 7(1):59-63.
Spilioti E, Jaakkola M, Tolonen T, LipponenM, Virtanen V, Chinou I, Kassi E, KarabourniotiS, Moutsatsou P. Phenolic acid composition,antiatherogenic and anticancer potential ofhoneys derived from various regions in Greece.PLoS One. 2014; 9(4): e94860.
Kassim M, Mansor M, Suhaimi A, OngG, Yusoff KM. Gelam honey scavengesperoxynitrite during the immune response. Int JMol Sci. 2012; 13 (9): 12113-29.
Fauzi AN, Norazmi MN, Yaacob NS. Tualanghoney induces apoptosis and disrupts the mitochondrial membrane potential of humanbreast and cervical cancer cell lines. Food ChemToxicol. 2011; 49 (4): 871-8.
Jaganathan SK, Mandal M. Honey constituentsand their apoptotic effect in colon cancer cells.Journal of Api Product and Api Medical Science.2009; 1 (2): 29 –36.
Khalil MI, Sulaiman SA. The potential role ofhoney and its polyphenols in preventing heartdiseases: a review. Afr J Tradit ComplementAltern Med. 2010; 7 (4): 315-21.
Beretta G, Orioli M, Facino RM. Antioxidant andradical scavenging activity of honey inendothelial cell cultures (EA.hy 926). PlantaMed. 2007; 73 (11): 1182-9.
Michiels C, Raes M, Toussaint O, Remacle J.Importance of Se-glutathione peroxidase,catalase, and Cu/Zn Free Radic Biol Med. 1994;17 (3): 235-48.
Jendeková L, Kojsová S, AndriantsitohainaR, Pechánová O. The time-dependent effect ofprovinols on brain NO synthase activity in LNAME-induced hypertension. Physiol Res. 2006;55 Suppl 1:S31-7.
Najafi M, Shaseb E, Ghaffary S, Fakhrju A,Oskouei TE. Effects of chronic oraladministration of natural honey on ischemia/reperfusion-induced arrhythmias in isolated ratheart. Iran J Basic Med Sci. 2001; 14 (1): 75-81.
Nasrolahi O, Heidari R, Rahmani F, Farokhi F.Effect of natural honey from Ilam andmetformin for improving glycemic control in streptozotocin induced diabetic rats. Avicenna JPhytomed. 2012; 2 (4): 212-21.
Erejuwa OO, Sulaiman SA, WahabMS, Sirajudeen KN, Salleh MS, Gurtu S.Glibenclamide or metformin combined withhoney improves glycemic control instreptozotocin-induced diabetic rats. Int J BiolSci. 2011; 7 (2): 244–252.
Akhtar MS, Khan MS. Glycaemic responses tothree different honeys given to normal andalloxan-diabetic rabbits. J Pak Med Assoc.1989;39: 107-13.
Fasanmade AA, Alabi OT. Differential effect ofhoney on selected variables in alloxan-inducedand fructose-induced diabetic rats. Afr J BiomedRes. 2008; 11: 191-6.
Erejuwa OO, Sulaiman SA, Wahab MS. Honey –A novel antidiabetic agent. Int J Biol Sci. 2012;8: 913–34.
Sani NF, Belani LK, Sin CP, Rahman SN, DasS, Chi TZ, Makpol S, Yusof YA. Effect of thecombination of gelam honey and ginger onoxidative stress and metabolic profile instreptozotocin-induced diabetic Sprague-Dawleyrats. Biomed Res Int. 2014; 16, 160695.
Batumalaie K, Qvist R, Yusof KM, IsmailIS, Sekaran SD. The antioxidant effect of theMalaysian Gelam honey on pancreatic hamstercells cultured under hyperglycemic conditions.Clin Exp Med. 2014; 14 (2): 185-95.
Al-Waili NS. Intravenous and intrapulmonaryadministration of honey solution to healthysheep: effects on blood sugar, renal and liverfunction tests, bone marrow function, lipidprofile, and carbon tetrachloride-induced liverinjury. J Med Food. 2003; 6 (3): 231-47.
Chepulis L, Starkey N. The long term effects offeeding honey compared with sucrose anda sugar-free diet on weight gain, lipid profiles,and DEXA measurements in rats. J Food Sci.2008; 73 (1): H 1-7.
Erejuwa OO, Sulaiman SA, Wahab MS, SalamSK, Salleh MS, Gurtu S. Comparison ofantioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys ofstreptozotocin-induced diabetic rats. Int J MolSci. 2011; 12 (1): 829-43.
Bogdanov S, Jurendic T, Sieber R, Gallmann P.Honey for nutrition and health: a review. J AmColl Nutr. 2008; 27 (6): 677-89.
Abdulrhman M, El-Hefnawy M, Hussein R, El-Goud AA. The glycemic and peak incrementalindices of honey, sucrose and glucose in patientswith type 1 diabetes mellitus: effects on Cpeptidelevel-a pilot study. Acta Diabetol. 2011;48 (2): 89-94.
Yaghoobi N, Al-Waili N, Ghayour-Mobarhan M,Parizadeh SM, Abasalti Z, Yaghoobi Z,Yaghoobi F, Esmaeili H, Kazemi-Bajestani SM,Aghasizadeh R,Saloom KY, Ferns GA. Naturalhoney and cardiovascular risk factors; effects onblood glucose, cholesterol, triacylglycerole, CRP,and body weight compared with sucrose. SciWorld J. 2008; 20; 8: 463-9.
Al-Waili N. Intrapulmonary administration ofnatural honey solution, hyperosmolar dextrose orhypo-osmolar distill water to normal individualsand to patients with type-2 diabetes mellitus orhypertension: their effects on blood glucoselevel, plasma insulin and C-peptide, bloodpressure and peaked expiratory flow rate. Eur JMed Res. 2003; 8 (7): 295-303.
Shambaugh P, Worthington V, Herbert JH.Differential effects of honey, sucrose, andfructose on blood sugar levels. J ManipulativePhysiol Ther. 1990; 13 (6): 322-5.
Larson-Meyer DE, Willis KS, Willis LM, AustinKJ, Hart AM, Breton AB, Alexander BM. Effectof honey versus sucrose on appetite, appetiteregulatinghormones, and post-mealthermogenesis. J Am Coll Nutr. 2010; 29 (5):482-93.
Al-Waili NS. Natural honey lowers plasmaglucose, C-reactive protein, homocyseine, andblood lipids in healthy, diabetic, andhyperlipidemic subjects: comparison withdextrose and sucrose. J Med Food. 2004; 7 (1):100-7.
Derakhshandeh-Rishehri SM, Heidari-Beni M,Feizi A, Askari GR, Entezari MH. Effectof honey vinegar syrup on blood sugar and lipidprofile in healthy subjects. Int J Prev Med. 2014;5 (12): 1608-15.
Samanta A, Burden AC, Jones GR. Plasmaglucose responses to glucose, sucrose, and honeyin patients with diabetes mellitus: an analysis ofglycemic and peak incremental indices. DiabetMed. 1985; 2 (5): 371-3.
Abdulrhman M, El Hefnawy M, Ali R, AbdelHamid I, Abou El-Goud A, Refai D. Effects ofhoney, sucrose and glucose on blood glucose andC-peptide in patients with type 1 diabetesmellitus. Complement Ther Clin Pract. 2013; 19(1): 15-9.
Abdulrhman MM, El-Hefnawy MH, Aly RH,Shatla RH, Mamdouh RM, Mahmoud DM,Mohamed WS. Metabolic effects of honey intype 1 diabetes mellitus: a randomized crossoverpilot study. J Med Food. 2013; 16 (1): 66-72.
Agrawal OP, Pachauri A, Yadav H, UrmilaJ, Goswamy HM, Chapperwal A, Bisen PS,Prasad GB. Subjects with impaired glucosetolerance exhibit a high degree of toleranceto honey. J Med Food. 2007; 10 (3): 473-8.
Bornet F, Haardt MJ, Costagliola D, Blayo A,Slama G. Sucrose or honey at breakfast have noadditional acute hyperglycaemic effect over anisoglucidic amount of bread in type 2 diabeticpatients. Diabetologia. 1985; 28 (4): 213-7.
Katsilambros NL, Philippides P, TouliatouA, Georgakopoulos K, Kofotzouli L, FrangakiD, Siskoudis P, Marangos M, Sfikakis P.Metabolic effects of honey (alone or combinedwith other foods) in type II diabetics. ActaDiabetol Lat. 1988; 25 (3): 197-203.
Whitfield P, Parry-Strong A, Walsh E,Weatherall M, Krebs JD. The effect of acinnamon- chromium- andmagnesiumformulatedhoney on glycaemic control, weightloss and lipid parameters in type 2 diabetes: anopenlabel cross-over randomized controlledtrial. Eur J Nutr. 2015; 19.
Bahrami M, Ataie-Jafari A, Hosseini S,Foruzanfar MH, Rahmani M, Pajouhi M.Effects of natural honey consumption in diabeticpatients: an 8-week randomized clinical trial. IntJ Food Sci Nutr. 2009; 60 (7): 618-26.
Münstedt K, Hoffmann S, Hauenschild A, BülteM, von Georgi R, Hackethal A. Effect of honeyn serum cholesterol and lipid values. J MedFood. 2009; 12 (3): 624-8.
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| Issue | Vol 2, No 1 (Winter 2016) | |
| Section | Original Article(s) | |
| Keywords | ||
| honey oxidative stress diabetes lipid | ||
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