Review Article

An updated systematic review on the effects of n-3 longchain polyunsaturated fatty acids on autistic spectrum disorder


Objectives: It has been suggested that omega-3 fatty acids deficiency could play a role in the pathogenesis of several psychiatric disorders, especially autism spectrum disorder (ASD). This systematic reviewof all available studieswas conducted to assess the efficacy of omega-3 fatty acid supplementations on the core features of ASD.
Methods: To find the relevant articles, databases including MEDLINE, EMBASE, PsycINFO, PubMed, Scopus and Cochrane between 1966 and December 2016 were searched. The criteria of selecting studies were English language; oral administration of n3 fatty acids supplements; clinical trials involving human patients with autism; and relationships between omega-3 fatty acids, DHA or EPA supplementation, as well as fish oil, and autism-related clinical- and social-related outcomes.
Results: We identified 337 articles in the systematic search, nine articles were finally chosen to be included in the review. Most studies have shown that omega-3 fatty acid supplementation can reduce hyperactivity and social problems in individuals diagnosedwith autism. However, no significant association has been reported between omega-3 fatty  acid supplementation as compared to placebo in behavioral abnormalities in most of the studies.
Conclusion: Based on the available literature, omega-3 fatty acids can act as an effective supplement in individuals with autism.

Lee YJ, Oh SH, Park C, Hong M, Lee AR, Yoo HJ, et al. Advanced pharmacotherapy evidenced by pathogenesis of autism spectrum disorder. Clin Psychopharmacol Neurosci 2014, 12(1), 19-30, DOI: 10.9758/cpn. - 2. Green VA, Pituch KA, Itchon J, Choi A, O’Reilly M, Sigafoos J. Internet survey of treatments used by parents of children with autism. Res Dev Disabil 2006, 27(1), 70-84. DOI :10.1016/j.ridd.2004.12.002. - 3. Meiri G, Bichovsky Y, Belmaker R. Omega 3 fatty acid treatment in autism. Child Adolesc Psychiatry 2009, 19(4), 449-451. DOI : 10.1089/cap.2008.0123 - 4. Madore C, Leyrolle Q, Lacabanne C, Benmamar-Badel A, Joffre C, Nadjar A, et al. Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota. Neural Plast 2016, 2016, 3597209. DOI: 10.1155/2016/3597209 - 5. Mazahery H, Conlon C, Beck KL, Kruger MC, Stonehouse W, Camargo CA, Jr., et al. Vitamin D and omega-3 fatty acid supplements in children with autism spectrum disorder: a study protocol for a factorial randomised, double-blind, placebo-controlled trial. Trials 2016, 17(1), 295. DOI: 10.1186/s13063-016-1428-8 - 6. Wong HH, Smith RG. Patterns of complementary and alternative medical therapy use in children diagnosed with autism spectrum disorders. J Autism Dev Disord, 2006,36(7), 901-9. DOI: 10.1007/s10803-006-0131-0 -7. Amminger GP, Berger GE, Schafer MR, Klier C, Friedrich MH, Feucht M. Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study. Biological psychiatry 2007, 15;61(4), 551-3. DOI: DOI: 10.1016/j.biopsych.2006.05.007 - 8. James S, Montgomery P, Williams K. Omega-3 fatty acids supplementation for autism spectrum disorders (ASD). Cochrane Database Syst Rev 2011, 09(11). DOI: 10.1002/14651858. - 9. Bent S, Hendren RL, Zandi T, Law K, Choi JE, Widjaja F, et al. Internet-based, randomized, controlled trial of omega-3 fatty acids for hyperactivity in autism. J Am Acad Child Adolesc Psychiatry 2014, 53(6), 658-66. DOI: 10.1016/j.jaac.2014.01.018. - 10. Voigt RG, Mellon MW, Katusic SK, Weaver AL, Matern D, Mellon B, et al. Dietary docosahexaenoic acid supplementation in children with autism. J Pediatr Gastroenterol Nutr 201458(6), 715-22. DOI: 10.1097/MPG.0000000000000260. - 11. Bent S, Bertoglio K, Ashwood P, Bostrom A, Hendren RL. A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder. J Autism Dev Disord 2011, 41(5), 545-54. DOI: 10.1007/s10803-010-1078-8 - 12. Ooi YP, Weng SJ, Jang LY, Low L, Seah J, Teo S, et al. Omega-3 fatty acids in the management of autism spectrum disorders: findings from an open-label pilot study in Singapore. EJCN 2015 , 69(8), 969-71. DOI: 10.1038/ejcn.2015.28 - 13. Mankad D, Dupuis A, Smile S, Roberts W, Brian J, Lui T, et al. A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism. Molecular autism. 2015, 6:18. DOI: 10.1186/s13229-015-0010-7. - 14. Yui K, Koshiba M, Nakamura S, Kobayashi Y. Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial. J Clin Psychopharmacol. 2012, 32(2):200-6. DOI: 10.1097/JCP.0b013e3182485791 -15. Politi P, Cena H, Comelli M, Marrone G, Allegri C, Emanuele E, et al. Behavioral effects of omega-3 fatty acid supplementation in young adults with severe autism: an open label study. Arch Med Res 2008, 39(7):682-5. DOI: 10.1016/j.arcmed.2008.06.005- 16. Gilotty L, Kenworthy L, Sirian L, Black DO, Wagner AE. Adaptive skills and executive function in autism spectrum disorders. Child Neuropsychol 2002, 8(4):241-8. DOI: 10.1076/chin. - 17. Meiri G, Bichovsky Y, Belmaker RH. Omega 3 fatty acid treatment in autism. J Child Adolesc Psychopharmacol. 2009, 19(4):449-51. DOI: 10.1089/cap.2008.0123 - 18. Politi P, Rocchetti M, Emanuele E, Rondanelli M, Barale F. Randomized placebo-controlled trials of omega-3 polyunsaturated fatty acids in psychiatric disorders: a review of the current literature. Curr Drug Discov Technol 2013, 10(3):245-53. PMID: 21838664 - 19. Hibbeln JR. Fish consumption and major depression. Lancet 1998, 351(9110),1213. DOI: 10.1016/S0140-6736(05)79168-6. -20. Noaghiul S, Hibbeln JR. Cross-national comparisons of seafood consumption and rates of bipolar disorders. Am J Psychiatry. 2003, 160(12):2222-7. DOI: 10.1176/appi.ajp.160.12.2222 -21. McNamara RK, Carlson SE. Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukot Essent Fatty Acids 2006,75(4), 329-49. DOI: 10.1016/j.plefa.2006.07.010 - 22. Moriguchi T, Greiner RS, Salem N. Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. ‎J. Neurochem 2000, 75(6), 2563-73. PMID: 11080210 - 23. Moriguchi T, Salem N. Recovery of brain docosahexaenoate leads to recovery of spatial task performance. ‎J. Neurochem. 2003;87(2):297-309. PMID: 14511107 - 24. auman ML. Brief report: neuroanatomic observations of the brain in pervasive developmental disorders. J Autism Dev Disord 1996, 26(2):199-203. PMID: 8744485 - 25. Aylward EH, Minshew NJ, Field K, Sparks B, Singh N. Effects of age on brain volume and head circumference in autism. Neurology 2002, 59(2), 175-83. PMID: 12136053

IssueVol 4, No 1 (Winter 2018) QRcode
SectionReview Article(s)
Autism Behavior Omega-3 fatty acids Hyperactivity Social problems

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Rahimlou M, Rayyani E, Hosseini SA, Husain D. An updated systematic review on the effects of n-3 longchain polyunsaturated fatty acids on autistic spectrum disorder. J Nutr Sci & Diet. 4(1).