The effect of oral supplementation of cinnamon on weight loss and blood pressure in patients with type 2 diabetes: a randomized clinical trial

  • Tayebe Zamani Mail Department of Nutrition, School of Medical Science, Urmia University of Medical Sciences, Urmia, Iran
  • Fatemeh Esmaeli Shahmerzadi Department of Nutrition, School of Medical Science, Urmia University of Medical Sciences, Urmia, Iran
  • Rasol Zarrin Department of Nutrition, School of Medical Science, Urmia University of Medical Sciences, Urmia, Iran
Keywords:
Cinnamon, Weight, Blood Pressure, Type 2 Diabetes

Abstract

Objectives: Cinnamon, as a flavoring additive and a drug in traditional medicine, has a long history. Today, several studies have been carried out on the effects of cinnamon on blood glucose, obesity, and hypertension in type 2 diabetic patients. The aim of this study was to determine the effect of cinnamon powder onweight loss and blood pressure in patients with type 2 diabetes.
Materials and Methods: This study was a randomized double-blind clinical trial conducted for 3 months on 81 patients with type 2 diabetes from the city of Maku, Iran. Patients were randomly divided into 3 groups receiving (a) two 500- mg cinnamon capsules (n = 27), (b) four 500-mg capsules (n = 28), and (c) placebo (n = 26). The biochemical parameters, systolic and diastolic blood pressure, height, weight, waist circumference (WC), body mass index (BMI), and body fat and leanmass were measured at the beginning and end of the study. Data analysis was performed using SPSS 16 software. 
Results: The mean age of participants was 51.73 ± 6.40 years. Weight, BMI, and WC decreased significantly following the intervention in the group receiving the higher dose of cinnamon supplementation (p = 0.009). Statistically significantdifferences were also observable among the 3 groups in weight (p = 0.03), BMI (p = 0.02), WC (p = 0.02), fat mass (p = 0.03 , and lean mass (p = 0.04) after theintervention. There was no significant difference in systolic and diastolic blood  pressure between preintervention and postintervention values.
Conclusion: This study showed that supplementation with dietary cinnamonpowder in type 2 diabetic patients significantly decreases weight, BMI, WC, and body fat and increases lean mass.

References

Cho, N., D. Whiting, and N. Forouhi, IDF Diabetes Atlas, 2015, 2016.

https://www., I.D.F.A.d. and i.o.a.-d.A.S. 2015.

Mabry, R., et al., Gender differences in prevalence of the metabolic syndrome in Gulf Cooperation Council Countries: a systematic review. Diabetic Medicine, 2010. 27(5): p. 593-597.

Esteghamati, A., et al., The economic costs of diabetes: a population-based study in Tehran, Iran. Diabetologia, 2009. 52(8): p. 1520-1527.

Mancia, G., G. Grassi, and J. Redon, Manual of hypertension of the European Society of Hypertension. 2014: CRC Press.

Hamman, R.F., et al., Effect of weight loss with lifestyle intervention on risk of diabetes. Diabetes care, 2006. 29(9): p. 2102-2107.

Espeland, M., Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes care, 2007.

Shan, B., et al., Antibacterial properties and major bioactive components of cinnamon stick (Cinnamomum burmannii): activity against foodborne pathogenic bacteria. Journal of Agricultural and Food Chemistry, 2007. 55(14): p. 5484-5490.

Ranasinghe, P., et al., Medicinal properties of ‘true’cinnamon (Cinnamomum zeylanicum): a systematic review. BMC complementary and alternative medicine, 2013. 13(1): p. 275.

Ballai, M., In vitro Л nt¡ can di dal Activity of Cinnamomum verum. J. Med. Sci, 2008. 8(4): p. 425-428.

Akilen, R., et al., Effect of short-term administration of cinnamon on blood pressure in patients with prediabetes and type 2 diabetes. Nutrition, 2013. 29(10): p. 1192-1196.

Camacho, S., et al., Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying. Scientific reports, 2015. 5: p. 7919.

Liu, Y., et al., A dietary supplement containing cinnamon, chromium and carnosine decreases fasting plasma glucose and increases lean mass in overweight or obese pre-diabetic subjects: a randomized, placebo-controlled trial. PloS one, 2015. 10(9): p. e0138646.

Statistical Center of Iran, D.I.L.a.o.J.A.f.h.w.a.o.i.

Vafa, M.R., et al., Effects of Cinnamon Consumption on Glycemic Status, Lipid Profile and Body Composition in Type 2 Diabetes Patients. International journal of preventive medicine, 2012. 3(8).

Miller, C.T., et al., The effects of exercise training in addition to energy restriction on functional capacities and body composition in obese adults during weight loss: a systematic review. PLoS One, 2013. 8(11): p. e81692.

Atlantis, E., et al., Inverse associations between muscle mass, strength, and the metabolic syndrome. Metabolism, 2009. 58(7): p. 1013-1022.

Srikanthan, P., A.L. Hevener, and A.S. Karlamangla, Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. PloS one, 2010. 5(5): p. e10805.

Akilen, R., et al., Glycated haemoglobin and blood pressure‐lowering effect of cinnamon in multi‐ethnic Type 2 diabetic patients in the UK: a randomized, placebo‐controlled, double‐blind clinical trial. Diabetic Medicine, 2010. 27(10): p. 1159-1167.

Wainstein, J., et al., Dietary cinnamon supplementation and changes in systolic blood pressure in subjects with type 2 diabetes. Journal of medicinal food, 2011. 14(12): p. 1505-1510.

Qin, B., K.S. Panickar, and R.A. Anderson, Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. Journal of diabetes science and technology, 2010. 4(3): p. 685-693.

Published
2017-02-28
How to Cite
1.
Zamani T, Esmaeli Shahmerzadi F, Zarrin R. The effect of oral supplementation of cinnamon on weight loss and blood pressure in patients with type 2 diabetes: a randomized clinical trial. J Nutr Sci & Diet. 3(1).
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