An updated systematic review of the effects of n-3 long-chain polyunsaturated fatty acids on Autistic Spectrum Disorder

  • Mehran Rahimlou
  • Elham Rayyani
  • Seyed Ahmad Hosseini
  • Durdana Husain
Keywords: Autism, Behavior, Omega-3 fatty acids, Hyperactivity, Social problems


Background: It has been suggested that omega 3 fatty acids deficiency could be a cause of pathogenesis of several psychiatric disorders, especially autism spectrum disorder.Objectives: This systematic review of  all available studies  was conducted to assessing the efficacy of Omega 3 fatty acids supplementations on core features of Autistic Spectrum Disorder (ASD).Methods: In order to search the related articles databases including MEDLINE, EMBASE, PsycINFO, PubMed, Scopus and Cochrane from 1966 to December 2016 were searched. Criteria of selecting studies were english language, oral administration of n-3 fatty acids supplement, clinical trials involving human patients with autism and evaluating the relationship between Omega 3, DHA or EPA supplementation or fish oil and autism-related clinical- and social-related outcome.Results: We identified 337 articles in the systematic search. Nine articles were finally chosen to be included in this review. Most studies have shown that Omega 3 supplementation can reduce hyperactivity and social problems in individuals diagnosed with autism. But there was no significant association between omega 3 groups compared to placebo in behavioral abnormalities in most of the studies.Conclusion: Based on available documents, Omega 3 can act as an effective supplement in individuals with autism.


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How to Cite
Rahimlou M, Rayyani E, Hosseini SA, Husain D. An updated systematic review of the effects of n-3 long-chain polyunsaturated fatty acids on Autistic Spectrum Disorder. JNSD. 4(1).
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