Review Article

The Effects of Omega-3/6 Fatty Acids and Vitamin D on Children with Attention-deficit/hyperactivity Disorder (ADHD): A Narrative Review

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental syndrome very common among children. The main cause of this disorder is unknown, and it seems that a combination of genetic, biological, environmental, psychosocial, neurochemical, and nutritional factors are involved. Diet seems to be one of the etiological factors for ADHD, as lower levels of long-chain omega-3 fatty acids have been reported in children with ADHD. In the present study, we reviewed the studies on the relationship of omega-3/6 fatty acid and vitamin D supplementation with ADHD. A literature search was conducted in different databases including Google Scholar, Science Direct, SID, PubMed, and MagIran using the following keywords: omega-3/6 fatty acid, PUFA, ADHD, Vitamin D, and Nutrient. Fifty-two records were retrieved and 30 articles were finally included in the review. It was concluded that omega-3/6 fatty acids and vitamin D supplements have potential efficacy in decreasing the ADHD symptoms among children, but further studies are needed to find the underlying mechanisms of such treatments and to determine the optimal dose of these treatments and if it is better to be used as a single treatment or in combination with other medication.

- Goldman LS, Genel M, Bezman RJ, Slanetz PJ. 1998. Diagnosis and treatment of attention-deficit/hyperactivity-disorder in children and adolescents. JAMA 279:1100–1107.

- Elia J, Ambrosiani PJ, Rappoport JL. 1999. Treatment of attention- deficit-hyperactivity-disorder. New Engl J Med 11:780–788.

- Brown RT, Freeman WS, Perrin JM, Stein MT, Amler RW, Feldman HM, Pierce K, Wolraich ML. 2001. Prevalence and assessment of attention-deficit/hyperactivity disorder in primary care settings. Pediatrics 107:43–54.

- Sadock BJ, Sadock V A. Kaplan and Sadock s synopsis of psychiatry, behavioral clinical psychiatry.10 ed.Philadelphia: Lippincott,Williams & Wilkins; 2007:1206-17.

- Kliegman R, Stanton B, Geme J, Schor N,Behrman R. Nelson textbook of pediatrics.19th ed.USA: Saunders; 2011.p. .108-112

- Alagheband Rad J, Raufi F. Relation, attention, deficit and hyperactivity disorder with learning disorder in 7-12 age boys. Andishehva Raftar. 2001;6(2,3):32-36.Persian.

- Kouchakzadeh Talami, Sobhaneh, Asiyeh Namazi, and Marjaneh Zarkesh. "Symptoms Related to Attention Deficit Hyperactivity Disorder among Preschool Children based on parents report." Holistic Nursing and Midwifery Journal 25.1 (2015): 35-44.

- Castellons FX. Towar a pathophysiology of attention deficit/hyperactivity. Clinical pediatr.2008;(36):370-383.

- Abdollahian E, Shakeri M, Vosough E. The prevalence of attention deficit and hyperactivity disorder in preschool-age children in Mashhad, north-east of Iran. Medical Journal of Mashhad University of Medical Science. 2004;47(84):275- 280.Persian.

- Lange K, Reichl S, Lange K, Toucha L, Tucha O. The history of attention deficit hyperactivity disorder. Atten Defic Hyperact Disord. 2010 Dec;2(4):241-55. doi: 10.1007/s12402- 010-0045-8. Epub 2010 Nov 30.

- Conner DF. Preschool attention deficit–hyper activity disorder: are view oprevalence diagnosis neurobiology and stimulant. Dev Behar pediatr.2002;10(2):41-59.

- Moradi A, Mohammadalizadeh S, Alai V, Fakhari A, Asadollahi M. Sign attention deficit hyperactivity disorder in preschool age children on base parents reported in kindergardens. Daneshvar journal. 2006;12(57):47-54.Persian.

- Stevens LJ, Zentall SS, Deck JL, Abate ML, Watkins BA, Lipp SR, Burgess JR. 1995. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 62: 761 – 768.

- Burgess JR, Stevens L, Zhang W, Peck L. 2000. Long-chain polyunsaturated fatty acids in children with attention- deficit hyperactivity disorder. Am J Clin Nutr 71(suppl): 327S – 330S.

- Germano, Michele, et al. "Plasma, red blood cells phospholipids and clinical evaluation after long chain omega-3 supplementation in children with attention deficit hyperactivity disorder (ADHD)." Nutritional neuroscience 10.1-2 (2007): 1-9.

- Farhud D, Shalileh M. Relation Between Omega 3 fatty acid, Iron, Zinc and Etiopathology and Treatment of ADHD. Zahedan J Res Med Sci (ZJRMS) 1-6.

- Jafarian, Kurosh; Nachvak, Seyed Mostafa; Salehi, Hamideh. 2013. A Review on the Effects of Omega-3 Supplementation on Sleep Patterns, Hyperactivity and other Developmental Behavior in Children with Autism Spectrum Disorders. Journal of Exceptional Children 13(1)

- Eckert, G P. PHARMAKON, Volume 2, Number 1, January 2014, pp. 60-69(10)

- Hosseini, Seyed Ebrahim, Mozhde Heidari, and Heydar Aqababa. "The effect of salmon fish’s oil on avoidance learning in mature male rats." Journal of Fasa University of Medical Sciences 3.2 (2013): 169-173.

- Hariri, M. et al. "Effects of dietary supplementation of omega-3 fatty acids on hyperactivity and serum inflammatory mediators in children with attention-deficit-hyperactivity disorder." Journal of School of Public Health and Institute of Public Health Research 9.3 (2012): 45-54.

- Crippa, A. et al. "Polyunsaturated Fatty Acids Are Associated With Behavior But Not With Cognition in Children With and Without ADHD An Italian study." Journal of attention disorders (2016): 1087054716629215.

- Chang, Jane Pei-Chen, et al. "Delay Aversion, Temporal Processing, and N-3 Fatty Acids Intake in Children With Attention-Deficit/Hyperactivity Disorder (ADHD)." Clinical Psychological Science 4.6 (2016): 1094-1103.

- Mortimer‐Cawley, Rachel, and Imran Mushtaq. "Nice Adhd addendum." Progress in Neurology and Psychiatry 20.3 (2016): 6-7.

- Patrick, Rhonda P., and Bruce N. Ames. "Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior." The FASEB Journal 29.6 (2015): 2207-2222.

- Ariyasinghe, D., and S. S. Williams. "Omega-3 fatty acids in psychological disorders." Sri Lanka Journal of Psychiatry 7.2 (2016).

- Barragán, Eduardo, Dieter Breuer, and Manfred Döpfner. "Efficacy and safety of omega-3/6 fatty acids, methylphenidate, and a combined treatment in children with ADHD." Journal of attention disorders (2014): 1087054713518239.

- Bloch MH, Qawasmi A. Omega-3 fatty acid supple- mentation for the treatment of children with attention- deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 2011; 50(10): 991-1000.

- Königs, Anja, and Amanda J. Kiliaan. "Critical appraisal of omega-3 fatty acids in attention-deficit/hyperactivity disorder treatment." Neuropsychiatric Disease and Treatment 12 (2016): 1869.

- Assareh, Marzieh, et al. "Efficacy of polyunsaturated fatty acids (PUFA) in the treatment of attention deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled clinical trial." Journal of attention disorders 21.1 (2017): 78-85.

- Johnson, Mats, et al. "Omega 3/6 fatty acids for reading in children: a randomized, double‐blind, placebo‐controlled trial in 9‐year‐old mainstream school children in Sweden." Journal of Child Psychology and Psychiatry 58.1 (2017): 83-93.

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IssueVol 3, No 4 (Autumn 2017) QRcode
SectionReview Article(s)
Keywords
ADHD Omega-3/6 fatty acids Vitamin D Nutrient supplements

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How to Cite
1.
Pourkazemi R, Asadi M, Paknahad Z. The Effects of Omega-3/6 Fatty Acids and Vitamin D on Children with Attention-deficit/hyperactivity Disorder (ADHD): A Narrative Review. J Nutr Sci & Diet. 2017;3(4):28-31.