Tehran University of Medical Sciences Journal of Nutritional Sciences and Dietetics 5 3-4 2020 09 27 276 276 Leila Momeni Department of Sport Physiology, Shoushtar Branch, Islamic Azad University, Shoushtar, Iran Hadi Fathi Moghadam Department of Physiology, Faculty of Medicine & Physiology Research Center, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran Seyed Hosseini Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Masoud Nikbakht Department of Physical Education and Sport Sciences, Ahwaz University, Ahwaz, Iran 2019 06 18 2020 02 15 Background: Cadmium can damage various tissues, including the liver, by fragmenting DNA of cells through increasing free radicals and reactive oxygen species (ROS) as well as inhibition of apoptotic suppressor proteins. Objectives: The purpose of this study was to investigate the interactive effects of endurance training and selenium consumption on the intrinsic apoptosis pathway in the liver tissue ofcadmium-exposed rats. Methods: In this experimental study, 30 rats were selected and divided into six groups of five subjects: (1) control, (2) selenium consumption, (3) high intensity interval training (HIIT), (4) continuous training, (5) HIIT with selenium, and (6) continuous trainingwithselenium.All rats peritoneally received 2 mg/kg of body weight cadmium for eight weeks. Rats in groups 2, 5 and 6 received0.23 mg/kg of selenium daily.Also, groups 3 to6 performed three sessionsof continuous and high intensity interval training for eight weeks. Two-way ANOVA along with Bonferroni's pairwise comparison test was used to analyze the findings of the research (P≤0.05). Results: Training increased Bcl-2 in the liver tissue of cadmium-exposed rats (p≤0.05);also, HIIT had a greater effect on Bcl-2 than continuous training (p ≤0.05).Selenium consumption reduced Bax and increased Bcl-2 in the liver tissue of cadmium-exposed rats (p≤0.05); on the other hand, exercise trainingand selenium consumption had interactive effects on decreasing caspase-9 and Bax and increasing Bcl-2 expression in the liver tissue of rats exposed to cadmium (p ≤0.05). Conclusions: Endurance training along with selenium consumption seems to have interactive effects on improving the process of liver apoptosis in rats exposed to cadmium. https://jnsd.tums.ac.ir/index.php/jnsd/article/view/276