Tehran University of Medical Sciences Journal of Nutritional Sciences and Dietetics 3 4 2017 10 12 14 21 EN Elham Mohammadzadeh Biochemistry of Nutrition Research Center; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mahla Arabpour Dahoue Biochemistry of Nutrition Research Center; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Amirhosein Sahebkar Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Tayebeh Kianoush Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Amir Avan Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Pouya Nezafati Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran AND Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. Fatemeh Sadabadi Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hamideh Ghazizadeh Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Sara Safar Soflaei Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mahsa Mohammadzadeh Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Samira Nasrfard Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Safarian Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Abdolreza Norouzi Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran seyed Mohammad Reza Parizadeh Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Majid Ghayour-Mobarhan Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 2017 09 22 2019 02 22 Background: Although dietary management is the principle intervention for treating obesity, noninvasive body-contouring methods are also gaining currency. We aimed to explore the effects of combined radiofrequency (RF) and ultrasound (US) body contouring on anthropometric indices, hematological markers, and anti-HSP27 levels in overweight females. Methods: In this randomized control clinical trial, fifty overweight females were enrolled and divided into two groups. Each participant was prescribed a diet with a daily calorie deficit of 500 kcal. RF and US were each used once a week for 5 weeks in the intervention group. Anthropometric and hematological markers were measured in all subjects before and after the intervention. Results: Abdominal circumference (AC), waist circumference (WC), body mass index, and body fat mass were reduced significantly in both groups (p < 0.001). However, the mean reduction in AC (p < 0.05) and WC (p < 0.001) were significantly greater in the intervention group compared with the control group. Moreover, levels of WBC, HCT, Hb, MCV, and MCH were significantly reduced after the RF-US intervention, although all the changes were in the normal range, suggesting that this therapy did not have adverse effects on hematological parameters. Also, the level of anti-HSP27 did not show any significant change. Conclusion: Our study suggests that body-contouring devices based on RF and US cavitation reduce measures of adiposity and do not have adverse effects on hematological factors, liver function markers, and HSP27 level in overweight women. Further investigations are required to explore the value of this method in a larger multicenter setting. https://jnsd.tums.ac.ir/index.php/jnsd/article/view/188