Tehran University of Medical Sciences Journal of Nutritional Sciences and Dietetics 1 2 2015 10 05 107 113 EN Laleh Keramat Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Mohammadreza Eshraghian Department of Biostatistics and Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mahmoud Djalali Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Gity Sotoudeh Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran Universityof Medical Sciences, Tehran, Iran Haleh Sadrzadeh-Yeganeh Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Fariba Koohdani Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, AND Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 2015 10 05 2015 10 05 Background: The objective was to investigate the relationship between serum interleukin-18 (IL-18), pentraxin 3 (PTX3), and high-sensitivity C-reactive protein (hs-CRP) levels with body mass index (BMI) and abdominal obesity and also the interaction between genetic variants of apolipoprotein A-II (Apo A-II) and obesity on the levels of these factors in type 2 diabetes patients (T2D). Methods:  A  comparative  cross-sectional study  was  conducted  in  21  diabetes centers in Tehran. Totally, 180 (35-65 years) T2D patients were divided into two groups of 90 obese (BMI ≥ 30) and 90 non-obese (BMI < 30), according to the BMI with equal numbers of each genotype of Apo A-II: 30 TT, 30 CC, and 30 TC. Serum IL-18, PTX3, and hs-CRP concentrations were compared between two obese  and  non-obese  groups  and  between  subjects  with  and  without  central obesity. To investigate the interaction of Apo A-II genetic variants and BMI with inflammatory factors, general linear model was used. Results: After adjusting data with confounding factors, the mean of serum PTX3 was significantly lower (p < 0.050) in the obese diabetes than non-obese diabetes subjects. Moreover, obese diabetes had higher serum hs-CRP level that on obese subjects (p < 0.010). No significant interaction between Apo A-II 265 T > C polymorphism and BMI on inflammatory biomarkers was observed. Conclusion: There was a significant difference in inflammatory markers (PTX3 and hs-CRP concentration) between obese and non-obese diabetes. In addition, there was no interaction of Apo A-II 265 T > C genotypes and BMI on inflammatory markers. Weight control may be recommended to modulate inflammation and its complications in obese patients. https://jnsd.tums.ac.ir/index.php/jnsd/article/view/16 https://jnsd.tums.ac.ir/index.php/jnsd/article/download/16/16