Tehran University of Medical Sciences Journal of Nutritional Sciences and Dietetics 3 2 2017 09 28 15 22 EN Matin Ghanavati Community Nutrition Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute (WHO Collaborating Center), Shahid Beheshti University of Medical Sciences, Tehran, Iran Meysam Alipour Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran Mehdi Khodaparast-Zavareh Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran1336616351, Iran Raziye Sarli Community Nutrition Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute (WHO Collaborating Center), Shahid Beheshti University of Medical Sciences, Tehran, Iran Bahram Rashidkhani Community Nutrition Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute (WHO Collaborating Center), Shahid Beheshti University of Medical Sciences, Tehran, Iran 2017 08 02 2017 08 17 Aim: This study was done to evaluate the relationship between dietary intake of some macronutrients, carotenoids, vitamins C, E, and A, and selenium and the risk of cataract. Methods: In this case-control study, dietary intakes of 97 cataract patients and 198 controls were assessed using a valid semi-quantitative food frequency questionnaire. Cataract was diagnosed using a slit-lamp examination and defined as any lens opacity in either eye. The associations between cataract incidence and quartiles of macronutrient and micronutrient intakes were investigated using logistic regression models. Results: After adjusting for the effects of confounding variables, the risk of cataract was significantly low in the highest nutrient intake quartile relative to the lowest quartile for fruits (OR = 0.15; 95% CI = 0.05-0.30) and vegetables (OR= 0.20; 95% CI = 0.08-0.40). We found significant, inverse associations of cataract with high dietary intake of vitamin C (OR = 0.22; 95% CI = 0.09-0.54), alpha-carotene (OR = 0.24; 95% CI = 0.10-0.58), beta-carotene (OR = 0.15; 95% CI = 0.05-0.39), lutein/zeaxanthin (OR = 0.19; 95% CI = 0.08-0.45), and beta-cryptoxanthin (OR = 0.05; 95% CI = 0.01-0.15). Conclusion: High daily intakes of fruits and vegetables and some dietary antioxidants might be associated with a decrease in cataract risk in Tehran, Iran. https://jnsd.tums.ac.ir/index.php/jnsd/article/view/138 https://jnsd.tums.ac.ir/index.php/jnsd/article/download/138/192